For
most people, the diagnosis of genital
herpes (Herpes Simplex Virus 2 or HSV2) is a shock. For others, the
diagnosis maybe a confirmation of suspicions they have had about their own
health or their partner’s behavior. Seeking to answer the question of how the
patient contracted the condition often leads to a search for blame and then
self-recrimination. Living with herpes is something that initially may take
some psychological adjustment for some patients. It need not mean the end of
your sex life or that you will need to remain celibate for the rest of your
life.
Firstly
HSV2 and HSV1, better known as the cold sore virus, are just two of a related
group of seven viruses that are known to infect humans. Others include the
Varicella-Zoster virus, commonly known as chicken pox and shingles. Diagnosis
of infection with either HSV1 or 2 can be established with a blood test known
as the Western Blot test; the upside of this test is that a patient who does
not have active lesions may be diagnosed through the presence of antibodies to
either strain. Accuracy of this test is only 90-95% depending on the lab
involved. Some instances have occurred where patients were diagnosed with
either a false positive or a false negative. The most accurate diagnosis is
with a physician taking the top off a fresh lesion, obtaining a swab from the
base of the lesion and a lab growing a viral culture from it. Extracting a
viable swab from the lesion can be quite painful for the patient.
HSV2
traditionally involved infections in genital areas, with the virus lying
dormant in the sacral nerve at the base of the spine during periods when the
patient is not experiencing lesions. HSV1 traditionally involves infections
around the mouth and nose and lies dormant in the trigeminal nerve in the neck
during non-active phases of the disease. Current epidemiology studies across
the Western World indicate the incidence of HSV2 to be around one in eight
people, or 12% of the population. Only one in five of those with antibodies
have been diagnosed.
In
real terms, in a room containing forty people, five have HSV2 but only one
knows they have it. A further three of the five may have had an isolated
symptom once or twice. This would have appeared so insignificant that they
mistook it for a pimple, infected hair follicle or a boil. The final one in
five is someone who has never had a symptom and may never do so. For this
patient, and the other three undiagnosed patients, accusations of infection
(generally followed by accusations of infidelity) from a partner are often met
with counter accusations and disbelief. A conservative estimate of the world
population with HSV1 antibodies and the ability to infect others is around 90%.
Of these, roughly 45% are symptomatic. If you have been diagnosed with either
infection, it is very possible you contracted it from someone who has no idea
they have it themselves.
People
have received the messages about safe sex and changed some of their practices,
believing that only penetrative sex requires safe sex. Sexual health
specialists now report that half the new HSV diagnoses in clinics have been
microbiologically confirmed as HSV1 on the genitals, in the general community
it is now estimated that 20% of all herpes infections in the genitals are in
fact HSV1. On the plus side for the infected patient, when the HSV virus is not
living in its ideal host environment (i.e. HSV1 infection of genitals, oral
HSV2 infection) infections have been generally documented to be less severe and
happen less frequently.
Another
mistake many patients make, is assuming that they are not infectious during a
dormant or asymptomatic phase of their disease. Studies have shown that even
when a couple who are clinically discordant (i.e. one is positive and the other
is negative) use what is recognized as gold standard treatment for reduction of
risk to partners, the rate of transmission in a 12-month period is still 10%.
This management of infection control involves the use of condoms during all
sexual encounters and complete abstinence from sex during the positive
partner’s symptomatic phases. Interestingly, sexual health experts report that
if one partner has remained negative for 10 years in a clinically discordant
partnership, it is very unlikely that they will contract the disease after this
time. It is speculated that they have some immunity/protection either natural
or acquired that science has not yet managed to identify.
A
true primary infection of HSV2 can last for up to ten days, it involves a
systemic response, where all the glands in the body are swollen, much as if the
patient has influenza, as well as the obvious genital burning, itching, pain
with urination or complete inability to urinate. Many patients think they are presenting
with a primary infection, but, severity of symptoms indicates to the physician,
this is in fact a recurrence. In these cases the patient’s primary infection
would have been asymptomatic, but, for some reason, they have become run down
and their immune system is not responding as it did when they were first
infected. These and subsequent recurrences of HSV2 are usually around five days
in duration, unless there is a serious immune system deficiency. In this case,
the treating physician should refer the patient for further testing.
Because
HSV transmission requires skin-to-skin contact and viral shedding to occur,
typically an infection of HSV2 is specifically confined to the genitals.
Affected areas include the vulva and labia in women and penis and scrotum in
men, due to penetrative intercourse being quite localized. Where a patient has
been infected with HSV1 on the genitals, the area is usually larger and vesicle
distribution more extensive due to oral sex skin-to-skin contact covering a
more extensive surface area of the genitals. Both viruses may be treated
effectively with anti-viral drugs.
As
stated earlier, each virus has its ideal host environment. For the patient
infected with HSV1 on the genitals, this means subsequent infections are usually
less virulent, and in some cases may only ever recur once or twice in their
lifetime. For the patient infected with
HSV2 on the genitals, the incidence of recurrence can vary greatly.
Recurrences are related to the health of the immune system. Triggers may
include stress, poor diet, lack of sleep, sunburn and in some women, their
menstrual cycle. During the first year of infection, the number of recurrences
may range from one to twelve, with an average being four to five. During
subsequent years the immune system responds better, the patient learns what
will trigger a recurrence and usually tries to avoid it. Eventually most
patients can experience as few as one to two recurrences per year. Also, as the
patient learns to better recognize the symptoms of an impending recurrence,
they are able to administer anti-viral drugs earlier. This can minimize the
length and duration of the attack, and possibly prevent lesions altogether. It
is important for the patient to remember that despite avoiding a recurrence, they
are still shedding the virus and they are still potentially infectious to their
partner.
Maintenance
doses of anti-virals may be taken daily to reduce the number of recurrences. Up
to 50% of patients on these therapies report an absence of recurrences in a
12-month period. Where this therapy is discontinued, patients almost certainly
will experience a recurrence within three weeks. This is generally followed by
a reduction in the number of annual recurrences. There are a small number of
female patients who have required this maintenance therapy with anti-viral
drugs continuously since they first became available, over 15 years ago, in
earlier forms. As recurrences reduce in frequency and severity, most patients
eventually come to terms with their diagnosis. For some, this is never the
case, sexual health physicians report that they need to refer between 10-20% of
their patients for further psychological counseling. This is in spite the fact
that they are very experienced with the disease counseling required for this
diagnosis.
About
Writer: Melanie
Addington is writer and ex herpes victims who write and to condense
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